One of the strongest themes that runs throughout six seasons of LOST is the potential conflict of science and faith.  From almost the beginning, Locke was the man of faith placed in contrast to Jack’s man of science.  It’s interesting to watch the characters change perspectives, especially in the first three seasons.  What are your presuppositions?  What new information do let shape your view?  Locke waffles when he learns more about the hatch.  Jack waffles when he understands the significance of the island after leaving it.  Here’s the confrontation from season one that really coalesced the conflict.